Phospholipid flippases: Building asymmetric membranes and transport vesicles
نویسندگان
چکیده
منابع مشابه
Phospholipid flippases: building asymmetric membranes and transport vesicles.
Phospholipid flippases in the type IV P-type ATPase family (P4-ATPases) are essential components of the Golgi, plasma membrane and endosomal system that play critical roles in membrane biogenesis. These pumps flip phospholipid across the bilayer to create an asymmetric membrane structure with substrate phospholipids, such as phosphatidylserine and phosphatidylethanolamine, enriched within the c...
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In eukaryotic cells, phosphatidylserine (PS) is predominantly located in the cytosolic leaflet of the plasma membrane; this asymmetry is generated by an unknown mechanism. In this study, we used the PS-specific probe mRFP-Lact-C2 to investigate the possible involvement of type 4 P-type ATPases, also called phospholipid flippases, in the generation of this asymmetry in Saccharomyces cerevisiae. ...
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The distribution of phospholipids across most, if not all, cell membranes is asymmetric. For example, around 80% of the sphingomyelin and phosphatidylcholine in erythrocyte membranes is localized in the exo (outer) leaflet, whereas 80-85% of the phosphatidylethanolamine and >96% of the phosphatidylserine is in the endo (inner) leaflet.1 A cell consumes significant amounts of chemical energy to ...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
سال: 2012
ISSN: 1388-1981
DOI: 10.1016/j.bbalip.2011.12.007